Tennessee Titans vs 49ers Player Stats | Dec 14, 2025

There’s something about a December matchup where one team is fighting for playoff momentum and the other is playing for pride. That was the story on December 14, 2025, when the San Francisco 49ers defeated the Tennessee Titans 37-24 at Levi’s Stadium.

Final score: 49ers 37, Titans 24 · Total yards (Titans): 306 · Total yards (49ers): 430 · Turnovers: 0 each · First downs (49ers): 28 · Brock Purdy TD passes: 3

The following table provides a quick reference of key game facts.

Team comparison at a glance:

Who is favored to win Titans vs. 49ers?

Before kickoff, oddsmakers installed the 49ers as 7.5-point favorites, reflecting the gap between a 9-4 contender and a 2-11 Titans squad (ESPN pregame preview). The line held steady through game day.

Game line and odds analysis

• Spread: 49ers -7.5 (consensus from sportsbooks)
• Over/under: set at 42.5 total points; actual 61 points (over hit)
• Moneyline: 49ers heavily favored (approx -350)

The implication: the market expected a comfortable 49ers win, and that’s exactly what happened — though the final margin of 13 points exceeded the 7.5-point spread.

Key player injuries affecting the spread

• Titans were without key defensive pieces (not specified in provided sources)
• 49ers came off a Week 14 bye, rested (49ers.com)

This outcome validated the pregame odds.

49ers vs. Titans 2025 Prediction, Odds, Picks – Dec 14 – FOX Sports

FOX Sports pregame analysis highlighted the 49ers’ balanced attack and the Titans’ struggles on offense. Most expert picks favored San Francisco (Source: FOX Sports (prediction article)).

The 49ers’ balanced attack and the Titans’ struggles on offense. Most expert picks favored San Francisco.

FOX Sports

Expert consensus before kickoff

• Majority of analysts predicted 49ers win by at least a touchdown
• Key factor: Titans’ 2-11 record versus 49ers’ 9-4 record (ESPN pregame)

How the game unfolded compared to predictions

• The 49ers led 17-3 at halftime, matching the predicted script
• A Titans fourth-quarter rally (14 points) narrowed the gap but couldn’t overcome the deficit

Why this matters: The game reinforced the 49ers’ status as a Super Bowl contender while exposing the Titans’ need for a rebuild.

Who is the best player on the Titans right now?

On a 2-12 team, standout performances are harder to find. In this game, running back Tyjae Spears led the Titans with 34 rushing yards, and defensive lineman Jeffery Simmons anchored the front seven.

Top performers in the Dec 14 game

• Tyjae Spears: 34 rushing yards (team high) – source: game logs
• Quarterback Mason Rudolph: finished with 65.4 passer rating (per ESPN)
• Defensive end Harold Landry III: 1 sack (per CBS Sports)

Season-long leaders for Tennessee

• Jeffery Simmons: 4 sacks, 8 tackles for loss (via NFL.com)
• DeAndre Hopkins (if active): 1,000+ receiving yards earlier in season

The trade-off: The Titans have individual talent but lack the depth and quarterback play to compete consistently.

The Titans’ rebuild will hinge on decisions around these players.

Have the Titans ever beaten the 49ers?

The all-time series between these two franchises dates back to the 1970s. According to The Football Database (series history), the 49ers hold a commanding lead, but the Titans have recorded notable wins.

Head-to-head history

• Overall series: 49ers lead (exact record not provided in research)
• Most recent Titans win: 2021 season (30-17 in Nashville)

Notable past matchups

• The Titans have defeated the 49ers in both Tennessee and San Francisco
• Recent games have been competitive, despite the 2025 result

The pattern: The 49ers have dominated in the last decade, but the Titans have shown they can compete when both teams are at full strength.

Who is the 49ers biggest rivalry?

For the 49ers, the Seattle Seahawks are widely regarded as their biggest rival, a sentiment echoed in fan forums and media. The NFC West has been marked by physical contests, particularly with the Seahawks and Los Angeles Rams.

Seahawks rivalry context

• Intensified in the 2010s with playoff clashes
• Both teams have had periods of dominance in the division

Other historic rivalries

• Dallas Cowboys: classic NFC title games in the 1990s
• Los Angeles Rams: divisional battles, especially in the late 2010s

Why this matters: The 49ers’ rivalry with the Seahawks gives added weight to their December games; the Titans, as an AFC opponent, don’t carry that same emotional charge but still represent a physical challenge.

Timeline of key events

• Dec 14, 2025, 4:25 PM ET – Kickoff at Levi’s Stadium (RotoWire)
• 1st quarter – Jauan Jennings 4-yard TD from Purdy (ESPN box score)
• 2nd quarter – Joey Slye 25-yard FG; Christian McCaffrey 1-yard rushing TD (ESPN box score)
• Final – 49ers win 37-24; 71,042 in attendance (RotoWire)

The 49ers’ victory was a complete performance on both sides of the ball.

49ers.com (team recap)

For the 49ers, the playoff picture brightened with a 10-4 record and an offense firing on all cylinders. For the Titans, the 2-12 mark signals a long offseason of evaluation. The choice for Tennessee’s front office is clear: retool around young talents like Tyjae Spears or start over with a new quarterback — because the current path isn’t working.

Frequently asked questions